Murad Mubarakiمراد علي مباركي

Oxidative stress is a major contributor to neurodegenerative diseases, triggering inflammation that ultimately leads to nerve cell death. This study aims to synthesize and characterize 2-(5-cyclopropyl-6-thioxo-1,3,5-thiadiazinan-3-yl) acetic acid COX-2 and scrutinize the neuroprotective efficacy in...

Current findings suggest that HSA-bound GML could be developed as a novel broad-spectrum antimicrobial agent targeting multidrug-resistant pathogens. Future research should focus on formulation optimization, in vivo efficacy studies, and preclinical evaluations to determine its therapeutic potential...

Abstract Coccidiosis, induced by Eimeria spp., substantially affects gastrointestinal health and results in economic detriments. This research examined juglone (5-hydroxy-1,4-naphthoquinone), a phenolic chemical, as a prospective in-silico and in vivo apoptotic and anticoccidial potential against Ei...

Abstract Helminthiasis is a global parasitic disease, and current anthelmintics like albendazole are costly, toxic, and increasingly ineffective due to resistance. Marine organisms, such as Holothuria polii , rich in bioactive compounds, are emerging as alternative therapeutic sources. This study ev...

Abstract Eimeriosis, caused by Eimeria spp., poses significant risks to veterinary health, and the frequent usage of coccidiostats has resulted in medication resistance. Therefore, this research studied the in vitro and in silico effects of Coriandrum sativum leaf extracts (CE), alongside an anticoc...

Stenotrophomonas maltophilia is a nonfermenting gram-negative bacterium associated with multiple nosocomial outbreaks. Antibiotic resistance increases healthcare costs, disease severity, and mortality. Multidrug-resistant infections (such as S. maltophilia infection) are difficult to treat with conv...

To determine the incidence of antimicrobial-resistant emerging pathogens, <i>Clostridium difficile</i>, and its associated risk factors in tertiary care setups of Pakistan. This cross-sectional prospective study was conducted from January 2019 to December 2020, to determine the prevalenc...

This study demonstrated that the study population exhibited a significant incidence of coinfections with intestinal helminth and viral malaria.

Background: Proteus mirabilis ( P. mirabilis ) is known to cause various infections, most commonly urinary tract infections, and is a threat to hospitalized patients, especially in long-stay departments that utilize invasive devices. This study aims to fill the knowledge gap regarding P. mirabilis e...

Proper management and control measurements are needed to stop the spread of highly pathogenic <i>E. coli</i> isolates that cause urinary tract infections (UTI) by developing new antibacterial agents to ensure the safety of public health. Therefore, the present investigations were used to...

Background: Malaria can infect erythrocytes and hence cause different pathogenesis episodes leading to death mostly in pregnant women and children under the age of 5 years. The selective pressure of these parasites leads to the production of new human genetic diseases. The most prevalent genetic alt...

Toxoplasmosis, neosporosis, and Q fever are among the most important abortifacient diseases in ruminants worldwide. These diseases result in huge economic losses in livestock besides the fact that some of are of public health concern. The present study aimed to update the data about the current sero...

<i>Background and Objectives</i>: Early detection of neonatal sepsis is critical because it is potentially fatal. Therefore, sepsis biomarkers of sufficient sensitivity and specificity are needed. This study aimed to evaluate the utility of peripheral blood parameters as neonatal sepsis ...

The incorporation of fermented camel milk with natural additives possesses numerous benefits for the treatment of various pathological and metabolic conditions. The present study investigated the impact of fortification of fermented camel milk with sage or mint leaves powder (1 and 1.5%, respectivel...

The overall prevalence rates of <i>Cryptosporidium</i> spp. and <i>G. duodenalis</i> were 1.8% (95% CI: 0.5-4.6) and 38.5% (95% CI: 32.0-45.3), respectively, in dogs, and 6.0% (95% CI: 2.6-11.4) and 32.1% (95% CI: 24.3-40.7), respectively, in cats. All canine and feline fecal...

Educational intervention may help increase students' awareness of <i>H. pylori</i> infections.

Ankylosing spondylitis (AS) is a chronic inflammatory disease that results in severe pain and stiffness in the joints. The causes and pathophysiology of AS are still largely unknown. The lncRNA H19 plays key roles in the pathogenesis of AS by mediating inflammatory progression by acting in the axis ...

Propolis is a natural agent produced by honeybees from several botanical sources. The purpose of our study is to evaluate the antitumor effect of propolis extract (PE) against urethane-induced lung cancer compared to Cisplatin (CIS) in rats. Some biochemical parameters of oxidative stress, gene expr...

Pomegranate is a long-known edible fruit with medicinal properties. Helminth infections are among the most common human illnesses worldwide, due to a lack of suitable sanitary systems and safe drinking water sources. Although these illnesses are seldom deadly, they cause development limitations in c...

Increasing rates of serious multi-drug resistant (MDR) <i>Pseudomonas aeruginosa</i> infections have been reported globally, including in Saudi Arabia. This retrospective study investigates the epidemiological, microbiological, and clinical characteristics of multi-resistant <i>P. ...

In this study, effective and environmentally friendly methods were used to achieve the synthesis of silver nanoparticles (Ag NPs) by an aqueous plant extract. The Ag NPs were synthesized via Zingiber officinale plant extract that acted as a reducing and stabilizing agent. Various techniques, includi...

<i>E. cloacae</i> is a prevalent nosocomial infection in which adult age is a significant risk factor for mortality. Moreover, this study emphasizes the importance of comparing <i>E. cloacae</i> resistance trends before and throughout the pandemic period in order to better un...

The identification of MDR-AB as a threat highlights the importance of surveillance studies in this region.

Abstract This study aimed to evaluate the prevalence and trends of transfusion-transmitted infections (TTIs) in two hospitals in Riyadh, as well as to judge the best type of tests to ensure blood transfusion safety. By using serological and nucleic acid test (NAT) tests, these donors were screened f...

The identification of <i>S. maltophilia</i> as a threat highlights the importance of surveillance studies in this region.

Toxoplasmosis is a zoonotic parasitic disease caused by T. gondii, an obligate intracellular apcomplexan zoonotic parasite that is geographically worldwide in distribution. The parasite infects humans and all warm-blooded animals and is highly prevalent in various geographical regions of the world, ...

Background and Objectives: In pre-eclampsia, restricted blood supply due to the lack of trophoblastic cell invasion and spiral artery remodeling is responsible for adverse pregnancies and maternal outcomes, which is added to by maternal undernutrition. This study was designed to observe the effect o...

Abstract The detailed description of parasites living in the areas of malaria endemic is essential to assess the achievement of current strategies of controlling malarial disease. The purpose of this study is to inspect the inherited multiplicity of the Plasmodium falciparum , obtained from malaria ...

Despite previous studies showing that Helicobacter pylori influences iron consumption, it is unknown what causes iron deficiency anemia in response to H. pylori infection. The goal of the study was to find out whether having an infection with H. pylori was linked to a drop-in serum iron level. Detec...

Human brucellosis is the most common zoonotic disease in the world. It is common infectious disease in Najran region, south western of Saudi Arabia. Several studies emphasized on the role of biochemical and hematological markers in clinical diagnosis of brucellosis, however to the best of our knowle...

<i>Background: Helicobacter pylori</i> (<i>H. pylori</i>), an important human pathogen, is classified as a human carcinogen. It is known to cause dyspepsia, peptic ulcers, and gastric cancer. Awareness regarding <i>H. pylori</i> infections in Saudi Arabia awaits i...

There is a growing awareness of the importance of incorporating behavioral changes into infectious disease treatments. In this study, we evaluated whether behavioral changes in mouse brains were altered following infection with the Trypanosoma evansi parasite. Infection significantly reduced locomot...

Telemedicine should be part of medical services but should not completely replace physicians' personal interaction. Telemedicine could be continued for stable remotely residing patients even after the COVID-19 pandemic.

Cancer patients undergoing radiotherapy displayed above-average levels of distress. This may have significant implications on their adherence for treatment and patient outcomes. Routine screening and support services or psychosocial care for patients are warranted among cancer patients undergoing ra...

Paracetamol is responsible for acute liver failure in humans and experimental animals when taken at high doses and transformed into a reactive metabolite by the liver cytochrome P450. On the other hand, nutmeg is rich with many phytochemical ingredients that are known for their ability to inhibit cy...

The peaceful phenomenon of the co-evolution between the prokaryotes (microbiota) and the eukaryotes (parasites including protozoa and helminths) in the animal gut has drawn the researchers' attention. Importantly, exploring the potential of helminths for therapeutic uses was one of the reasons ...

Competency is the basic standard for all healthcare professionals when providing care to recipients. The practice of good nursing begins primarily in the study of the nursing program and in the preparation of a nurse with high efficiency in nursing skills. This paper presents the concept of nursing ...

One of the most common deadliest parasitic diseases is Malaria. The biology and the pathogenesis of this fascinating parasite are not yet fully understood which make discovering effective alternative drugs a challenging task. Moreover, the emergence of resistant strains added an additional burden in...

Malaria is a major health problem that still affects numerous countries. The current study aimed to identify the role of <i>Indigofera oblongifolia</i> leaf extract in regulating mouse spleen macrophages during the progression of <i>Plasmodium chabaudi</i> infection. Three do...

Malaria is still taking the lead as one of the deadliest infectious diseases worldwide, appealing continuous research for further understanding the biology and the pathogenesis of this fascinating parasite. Discovering effective alternative drugs, however, remains a challenging task to address today...

The present study evaluates the synergistic effect of sulbactam/tazobactam in combination with meropenem or colistin against multidrug resistant (MDR) Acinetobacter baumannii isolated from hospitalized patients from a tertiary care hospital in Saudi Arabia. During the study period, 54 multidrug and ...

Malaria is a vector-borne parasitic disease spread by a bite of an infected female Anopheles mosquito that accounts for high morbidity and mortality, mainly in sub-Saharan Africa. Of the five species that can cause malaria in humans, Plasmodium falciparum is regarded the most virulent species. Antim...

Malaria is still one of the most devastating infectious diseases in the tropics. The present study aims to investigate the protective role of pomegranate peel extract against Plasmodium chabaudi-induced spleen tissue damage in mice. Animals were divided into three groups. Group I served as a vehicle...

There is an urgent need for new antimalarial drugs with novel mechanisms of action to deliver effective control and eradication programs. Parasite resistance to all existing antimalarial classes, including the artemisinins, has been reported during their clinical use. A failure to generate new antim...

An analysis of distress in flexible pavements for the urban street network at Riyadh city over 4 years is described. Pavement sections were categorized according to distress data, namely distress type, distress density, and distress severity as well as factors that can affect the behavior analysis s...