Manal Abudawoodمنال محمد لطفي أبود داؤود

E-cadherin, an adhesion molecule critical for epithelial integrity, may be downregulated by oxidative stress (OS) in diabetes. While serum E-cadherin has been investigated in various conditions, its presence in saliva and potential as a non-invasive biomarker for diabetes remain poorly understood. T...

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with rising incidence, treatment resistance, and chemotherapy-induced toxicity underscoring the need for safer, more effective therapeutic strategies. Nanotechnology offers a promising approach through targeted dr...

Rosai-Dorfman disease (RDD) has traditionally been viewed as a reactive histiocytic disorder, defined by its unique clinical features and immunophenotype. However, recent genetic studies suggest a more complex molecular landscape, challenging the notion of RDD as solely reactive and hinting at a pos...

The study highlights a potential association between Lu, Sm, Dy, and Ce and an increased risk of RPL, highlighting REE-induced toxicity as a major risk factor for RPL. The outcome of the study is to advance our understanding of the interplay between rare earth elements and RPL, with potential implic...

High blood pressure (BP) and dyslipidemia are major risk factors for cardiovascular disease mortality. The systemic immune-inflammation index (SII) has been suggested as a predictive tool to identify those at risk for chronic diseases, however, its use for predicting high BP and dyslipidemia has not...

<b>Background:</b> Lymphomas account for approximately 10% of all cancer cases among the Saudi population. Even when separated, Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) are in the top ten most commonly diagnosed cancers among Saudi men and women. Despite the substantial cost ...

<i>Background and objectives</i>: Low-grade inflammation is associated with metabolic disturbances like diabetes. The systemic immune-inflammation index (SII) has been proposed as a predictive tool to identify individuals at a greater risk of diabetes. This study aims to examine the asso...

Background: Advanced glycation end products (AGEs) in diabetic patients can trigger several autoimmune responses. This article aims to assess the presence of circulating autoantibodies against glycated histones and their role in complications in diabetic patients in the Saudi population. Methods: A ...

Colorectal cancer (CRC) is the commonest cancer in Saudi males and the third most common in Saudi females. Although CRC represents a major public health challenge, the resources to evaluate its burden are inadequate. This study aims to elucidate the magnitude of CRC incidence trends in the Saudi pop...

Dynamic 3D culture is desirable for the large-scale expansion of undifferentiated human IPSCs.

B cell Acute Lymphoblastic Leukemia (B-ALL) is one of the most common types of cancer diagnosed in children in Saudi Arabia. Cytogenetic investigations, including karyotyping and FISH, are used to determine the incidence and prognostic significance of chromosomal abnormalities in B-ALL. However, in ...

Objective: To synthesize magnesium oxide nanoparticles using ethanol extract of shoots of Plicosepalus curviflorus (PC-MgONPs) and evaluate the antimicrobial, antioxidant, and anti-proliferative activities of PC-MgONPs. Methods: The green synthesized PC-MgONPs were characterized by ultraviolet-visib...

Three major <i>PML-RARα</i> fusion gene transcripts (long [bcr1], variant [bcr2], and short [bcr3]) are currently used in clinical laboratories for the diagnosis and treatment monitoring of APL patients. Despite highly improved outcome, relapse and intracranial haemorrhage that may lead ...

This study identified phytochemicals in <i>Argemone mexicana (A. mexicana)</i> extracts that are responsible for its medicinal properties, and the best solvent for their extraction. The extracts of the stem, leaves, flowers, and fruits of <i>A. mexicana</i> were prepared at l...

Durian (<i>Durio zibethinus</i> L.) grows widely in Southeast Asia. The pulp of the durian fruit contains carbohydrates, proteins, lipids, fibers, various vitamins, minerals, and fatty acids. This study was carried out to elucidate the anticancer mechanism of action of the methanolic ext...

<i>Background and Objective</i>: Cisplatin is a chemotherapy drug used to treat several types of malignancies. It is a platinum-based compound that interferes with cell division and DNA replication. Cisplatin has been associated with renal damage. This study evaluates the early detection...

Exposure to long-term chronic unpredictable mild stress (CUMS) can cause redox imbalance and inflammation, which may affect the integrity of the gut barrier. The present study was conducted to investigate the effects of a probiotics bacterium mixture, including Clostridium butyricum (C. butyricum) a...

The plant <i>Brocchia cinerea</i> (Delile) (<i>B. cinerea</i>) has many uses in traditional pharmacology. Aqueous (BCAE) and ethanolic extracts (BCEE) obtained from the aerial parts can be used as an alternative to some synthetic drugs. In vitro, DPPH, FRAP and TAC are three ...

Isothiazolinone preservatives (methylisothiazolinone (MIT) and methylchloroisothiazolinone (CMIT) are commonly used in cosmetics, industrial and household products. However, these isothiazolinone derivatives are known to cause allergic contact dermatitis. Hence, a sensitive, accurate, and reliable m...

Humans exploit heavy metals for various industrial and economic reasons. Although some heavy metals are essential for normal physiology, others such as Tellurium (Te), Thallium (TI), antimony (Sb), and Osmium (Os) are highly toxic and can lead to Polycystic Ovarian Syndrome (PCOS), a common female f...

In the original publication [...]

our findings suggest that meat intake had an impact on the gut flora of Arab adult females, independent of adiposity. Specific strains identified in this study need further investigation to determine their relation to meat intake and obesity.

Polyphenols may modulate gut microbiota; however, limited studies have examined this relationship relative to obesity. We aim to investigate the association between polyphenol intake and gut microbiota composition in relation to obesity indices among Saudi Arabian females. This study included 92 adu...

Recent evidence has suggested that the gut microbiota is a possible risk factor for obesity. However, limited evidence is available on the association between the gut microbiota composition and obesity markers in the Middle-Eastern region. We aimed to investigate the association between gut microbio...

Due to poor diagnosis breast cancer in women has emerged as the most common cause of death disease in developing countries. Medicinal plants have been used for thousands of years and can be useful in healthcare, especially in developing countries. Ethanol extracts of leaves of fire bush or arta (<...

There is a paucity of detailed data related to the effect of senescence on the mitochondrial antioxidant capacity and redox state of senescent human cells. Activities of TCA cycle enzymes, respiratory chain complexes, hydrogen peroxide (H₂O₂), superoxide...

Most of the AML patients in remission develop multidrug resistance after the first-line therapy and relapse. AML stem cells have gained attention for their chemoresistance potentials. Chemoresistance is a multifactorial process resulting from altered survival signaling pathways and apoptosis regulat...

Selenium enhances the cellular antioxidant capacity and alleviates oxidative stress. We investigated the transcriptional and enzymatic activities of selenium-dependent glutathione peroxidase 1 and thioredoxin reductase 1 (TrxR1), and levels of glutathione, hydrogen peroxide, lipid peroxides, and pro...

Chronic respiratory diseases (CRDs) like asthma and chronic obstructive pulmonary disease (COPD) are the leading causes of morbidity and mortality worldwide. Alveolar macrophages (AM) are immune cells that exist in different polarization states/phenotypes and have been shown to play a critical role ...

No association was found between Vitamin D deficiency and both POAG and PACG among Saudi population despite low serum level of Vitamin D in glaucomatous and control subjects. This study suggested that Vitamin D level may not contribute in augmenting the severity and progression of glaucoma.

Candesartan cilexetil (CC) is an antihypertensive drug. It has low solubility and faces hepatic first-pass metabolism after oral ingestion. We formulated bioadhesive buccal films and studied the respective drug pharmacokinetics. Different bioadhesive films were prepared (40, 80, 120, 160, 200, and 2...

Inauhzin (INZ) is a novel p53 agonist with antitumor activity. Anemia is a common side effect of chemotherapy and may arise from red blood cell (RBC) hemolysis or eryptosis. In this study, we investigate the mechanisms of INZ toxicity in human RBCs. RBCs were isolated from healthy donors and treated...

Biomarker discovery would be an important tool in advancing and utilizing the concept of precision and personalized medicine in the clinic. Discovery of novel variants in local population provides confident targets for developing biomarkers for personalized medicine. We identified the need to genera...

Long-term continuous light exposure (CL) and western diet (WD) effects on Adropin expression, RORα, and Rev-erb-α nuclear receptors and energy homeostasis were studied in rats. Thirty-two male Wistar rats (250-290 g) were enrolled for 3 months in the following groups (<i>n</i> = 8/group)...

Abstract Polycystic ovary syndrome (PCOS) is a global health concern in women of reproductive age as 1/15 th women worldwide, is affected by this syndrome. PCOS is marked by hyperandrogenism, anovulation, menstrual abnormalities, and polycystic ovaries. Metals like arsenic, cadmium, lead and mercury...

Intrauterine growth restriction patients show a metabolic shift in favor of oxidation compared to HP women.

Discovery of novel variants from data derived from local population provides confident targets for developing biomarkers for personalized medicine. Biomarker discovery would be an important tool in advancing and utilizing the concept of precision and personalized medicine in the clinic. We identifie...

Green synthesis of silver nanoparticles (AgNPs) has consistently revolutionised the field of nanotechnology, and bio-based AgNPs have emerged as efficient therapeutic tools in biomedical science. The present work focused on the synthesis and characterisation of eco-friendly AgNPs from Brassica nigra...

The present study focused on the green synthesis of silver nanoparticles from <i>Coriander sativum</i> (CS) containing structural polymers, phenolic compounds and glycosidic bioactive macromolecules. Plant phenolic compounds can act as antioxidants, lignin, and attractants like flavonoid...

Oxidative stress and decreased antioxidant defenses are associated with DR progression to its PDR stage.

Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder with chronic hyperglycemia. Genome-wide association studies (GWAS) have identified many genes and, among them, solute carrier family 30 member 8 (SLC30A8) was one of the important genes linked to the development of T2DM risk. The relati...

A pro-inflammatory diet may have an adverse influence on stress and inflammatory biomarker levels among college students. The dietary inflammatory index (DII^®) is a tool used to assess the inflammatory potential of a diet. However, evidence for the association between DII and ...

Significantly (p less than 0.001) increased seminal ROS level with decreased TAS scores was observed in the infertile groups compared to normozoospermics. The infertile males showed marked elevated (p less than 0.001) levels of 4-HNE, DNA fragmentation and caspase-3 activity compared to normozoosper...

Type 2 Diabetes Mellitus (T2DM) is the most widely known type of disorder of the endocrine system marked by hyperglycemia resulting either due to deficiency of insulin and or resistance. Persistent hyperglycemia induces oxidative stress and is suggested to play a prominent role in the pathophysiolog...

Diabetes mellitus (DM) is a common worldwide endocrine disorder characterized by hyperglycemia resulting from defects in insulin secretion and insulin action or both. A number of clinical studies have investigated diabetes and its causal relation with neoplasm. Several epidemiological studies have f...

The aim of the present study was to examine the protective effect of curcumin (CUR) and curcumin nanoparticles (CURNPs) as antioxidants on the nephrotoxicity induced by lead (Pb). CUR (60 mg/kg b.w) and CURNPs (30 mg/kg b.w) were evaluated using Pb (30 mg/kg b.w.) induced oxidative renal damage in r...

The induced toxicity in the liver was corrected by pretreatment with HSP. The findings of this study suggest that HSP pretreatment can potentially be used to prevent nZnO-induced biochemical alterations toxicity. Further, protection by HSP on biochemical results was confirmed by histopathological ch...

[This corrects the article on p. 7789 in vol. 12, PMID: 29123393.].

Abnormal vitamin D level and glucose homeostasis are two most chronic medical conditions leading to cardiovascular disease following menopause transition in females. Low levels of vitamin D could be associated with elevated risk of type 2 diabetes mellitus (T2DM). The aim of the present study was to...

Silver nanoparticles (AgNPs) have attracted the most interest in terms of their potential biomedical and industrial applications. However, these nanoparticles have shown their toxic behavior toward environment, living tissues, and organisms. Selenium (Se), an essential trace element, is necessary fo...

The present study was designed to evaluate the effect of rutin (RT) on lead (Pb)-induced oxidative stress. Rats were divided into groups and were treated with RT with or without lead. Levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), tumor necrosis factor-α (TNF-α), inte...

Diabetes is a major risk factor for cardiovascular disease (CVD) including stroke, coronary heart disease, and peripheral artery disease. It remains a leading cause of mortality throughout the world, affecting both women and men. This investigation was aimed to study gender based differences in card...

It is concluded that QR could protect the liver against DNA damage induced by ACR probably is thus capable of ameliorating ACR-induced changes in the rat livers.

The findings demonstrate both a pro-angiogenic and protective effect of citicoline on hCMEC/D3 in vitro and following middle cerebral artery occlusion (MCAO) in vivo.