Fahad Aldakheelفهد محمد الدخيل

Background Rohitukine (RH) in Benzo[α]pyrene, an experimental model of cognitive and memory impairment, has not been reported yet. Hence, with the state of the art in repurposing techniques, we redefined the use of RH against CNS disorders, using Benzo[α]pyrene-induced mouse model of cognitive memor...

Background This study’s objectives are to ascertain the frequency of congenital tooth missing and evaluate the relationship between gender and side characteristics. Method This retrospective study involved participants who attended private dental clinics as well as a dental college in Hail, Saudi Ar...

[This corrects the article DOI: 10.3389/fimmu.2025.1595093.].

This study shows that <i>A. pegreffii</i> induces a dual-pronged immune response: ABP exacerbates inflammation, while glycoproteins suppress it. This highlights glycoproteins' potential as therapeutic targets for modulating parasitic immunopathology and inflammatory diseases. The an...

For centuries, a competitive evolutionary race between prokaryotes and related phages or other mobile genetic elements has led to the diversification of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR‑associated sequence (Cas) genome‑editing systems. Among the different...

This study presents a promising peptide-based vaccine candidate against hRSV that can effectively engage the immune system, showing strong immunogenicity and antigenicity. Future <i>in vitro</i> and <i>in vivo</i> studies are essential to evaluate the ability of the multi-epi...

Disulfovibrio (DSV) blooms are linked to gastrointestinal and systemic diseases due to their production of hydrogen sulfide, lipopolysaccharides (LPS), extracellular vesicles and mucolytic activity. Despite their health implications, targeted therapies are lacking. This novel study introduces a mult...

No difference in lifestyle patterns between e-cigarette users and nonsmokers may be due to lesser smoking duration since initiation. Longitudinal studies with diverse populations and a longer duration of e-cigarette use are recommended to explore the effects of e-cigarette smoking on lifestyle behav...

Background: E-cigarette use has been linked with multiple morbidities and changes in health behavior. This study investigates e cigarette use with sleep patterns, stress levels, and physical activity behavior and compare it with nonsmokers.Methods: A standardized electronic questionnaire for sleep, ...

Wound dressings used in medical applications serve as a protective barrier for wounds, creating an environment that promotes wound healing. The typical traditional wound dressings often present challenges, including weak barrier function and tendency to adhere to wounds. Therefore, there is a critic...

A higher prevalence of self-reported asthma was found among children with type 1 diabetes. Those with a family history of asthma may be considered for screening and educational programs.

Apigenin is a powerful flavone compound found in numerous fruits and vegetables, and it offers numerous health-promoting benefits. Many studies have evidenced that this compound has a potential role as an anti-inflammatory and antioxidant compound, making it a promising candidate for reducing the ri...

The Gels Editorial Office retracts the article, “Employing of Curcumin–Silver Nanoparticle-Incorporated Sodium Alginate-Co-Acacia Gum Film Hydrogels for Wound Dressing” [...]

This study investigates the effects of lotus root extract (LRE) on antioxidants and cancer prevention to understand how lotus can be used as a natural ingredient in health-promoting foods. We tested the extract's ability to neutralize harmful molecules using the DPPH assay and found that its ef...

Haematological abnormalities were found to be the most common among SLE patients. Further, the correlation between cytokine profile and haematological indices indicates the influence of cytokines in the development of haematological abnormalities. Understanding hematological abnormalities and cytoki...

Skin wound healing is time-consuming and frequently accompanied by bacterial infections and the development of scars. The rise of antibiotic-resistant bacterial strains has sparked a growing interest in naturally occurring bioactive substances, like curcumin, that possess wound-healing capabilities....

The prevalence of chronic wounds is increasing owing to the expanding population and the growing number of individuals suffering from diabetes. Such a chronic wound continues to be a significant healthcare burden for diabetic patients because it frequently carries a high chance of limb loss due to a...

Asthma affects a significant number of individuals in Saudi Arabia, with increasing prevalence worldwide, leading to a considerable impact on their quality of life and frequent hospitalizations. In this study, we aimed to explore the relationship between the immune cell ratio and coagulation markers...

Female infertility (FI) is a global health issue. Polycystic ovary syndrome (PCOS) is a common cause of FI. The renalase gene (<i>RNLS</i>) is associated with FI and other human diseases. Based on the documented missense variants, rs6166 and rs2296545 single-nucleotide polymorphisms (SNP...

Wound healing is a biological process that involves a series of consecutive process, and its impairment can lead to chronic wounds and various complications. Recently, there has been a growing interest in employing nanotechnology to enhance wound healing. Silver nanoparticles (AgNPs) have expanded s...

Silver nanoparticle composites have abundant biomedical applications due to their unique antibacterial properties. In the current work, green tea leaf extract was used as a natural reducing agent to synthesize AgNPs (AgNPs) using microwave irradiation technology. Furthermore, microwave irradiation h...

These findings suggested the increasing popularity of e-cigarette use among male first-year university students. More educational campaigns and stricter regulations are needed to curb this trend.

Peri-implantitis, characterized by inflammatory reactions resulting in bone loss around dental implants integrated with the jawbone, presents a significant challenge in implant dentistry. While bacterial biofilms are recognized as the primary culprits in peri-mucositis, peri-implantitis is often att...

Honey bee venom (BV) is a valuable product, and has a wide range of biological effects, and its use is rapidly increasing in apitherapy. Therefore, the current study, we reviewed the existing knowledge about BV composition and its numerous pharmacological properties for future research and use. Hone...

Glucometers are commonly used in a variety of healthcare settings and use in critically ill patients should not be assumed without appropriate tool validation. The study objective was to evaluate the accuracy of three point-of-care glucometers (POCGs) to assess glucose concentration in human blood s...

BHR and serum inflammatory cytokines have prognostic value in adults with spontaneous asthma remission. At-risk individuals with BHR, Th2-high or Th2-low cytokine profiles may benefit from closer monitoring and on-going follow-up.

Clinical and laboratory data of COVID-19 patients may help understanding the pathogenesis of the disease and subsequently improve of the outcome of patients by determination of the associated risk factors and recognition of high risk group who are more liable for complications and in hospital death....

Nanomedicine has been used as a precise treatment for many diseases. The advantage of using nanodrugs is that they have more permeability and less toxicity to cells, which enhances the drug delivery system. Graphene is well known for its potential biological applications in drug, food, and pharma in...

Considering that freshwater is a necessity for human life, sewage treatment has been a serious concern for an increasing number of scientists and academics in recent years. To clean industrial effluents, innovative catalysts with good adsorption, chemical stability, and physicochemical properties ha...

Alloantibodies are popularly transfusion-related and can be formed against many blood components including the red blood cells, white blood cells, and platelets. The formation of alloantibodies which is a common a sequence for repeated red blood cell transfusion has been reported and are clinically ...

The study findings indicated a high level of CVD risk knowledge in our study population. The presence of multidisciplinary intensive education programmes targeting type 2 DM patients, such as that conducted at KSUMC, might be responsible for the higher levels of knowledge among our study population....

To eradicate most infectious diseases, mathematical modelling of contagious diseases has revealed that a combination of quarantine, vaccination, and cure is frequently required. However, eradicating the disease will remain a difficult task if they aren't provided at the appropriate time and in ...

Abstract Two new copper( ii ) complexes [CuL 1 ] ( 1 ) and [CuL 2 ] ( 2 ) derived from azo-based ligands 2-hydroxy-5- p -tolylazo-benzaldehyde (HL 1 ) and 1-(2-hydroxy-5- p -tolylazo-phenyl)-ethan-one (HL 2 ) were synthesized. These two ligands and their metal complexes were characterized by element...

A critical factor in the cause and progression of Alzheimer's disease (AD) is the growth of <i>β</i>-amyloid peptide (A<i>β</i>) in the brain. The mechanism of this effect is still unknown, although the effect of osthol on A<i>β</i>-induced inflammation is ne...

Article Erratum to “Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies” was published on January 1, 2022 in the journal Open Chemistry (volume 20, issue 1).

To enhance the bioactivity of molecules through nanoparticles is being tested which has potential use in sustained-release drug delivery systems and to enhance the therapeutic effectiveness of drugs. Our current investigation s is to conjugate lectin to that of a gold nanoparticle (GNP) surface with...

Several studies suggested the role of heme iron, but not non-heme iron in colorectal cancer. A network and system biology-based approach was used to understand the role of heme and non-heme iron on colorectal cancer etiology. Heme and non-heme iron targets were screened in addition to CRC targets. T...

Despite the multiple systematic reviews and meta-analyses accumulating evidence on the preventive effect of calcium supplementation for colorectal cancer, most of the associated adverse effects are not systematically analyzed. The aim of the study is evaluating adverse events associated with calcium...

The prevalence of allergic diseases is regarded as one of the key challenges in health worldwide. Although the precise mechanisms underlying this rapid increase in prevalence are unknown, emerging evidence suggests that genetic and environmental factors play a significant role. The immune system, mi...

<i>Acinetobacter baumannii</i> has recently been increasing as an aggressive pathogen in immunocompromised persons. In the present study, we determined the in vitro antibacterial and anti-biofilm activity of thymoquinone (TQ) against <i>A. baumannii</i>. A liposomal formulati...

<i>C. perfringens</i> is a highly versatile bacteria of livestock and humans, causing enteritis (a common food-borne illness in humans), enterotoxaemia (in which toxins are formed in the intestine which damage and destroy organs, i.e., the brain), and gangrene (wound infection). There is...

Abstract Background The association between grass pollen exposure and lung function changes and airway inflammation is limited. We investigated these associations in a community-based sample, and whether any such associations were modified by current asthma, current hay fever, pollen sensitization a...

Antioxidants are involved in the process of cellular damage prevention, which is considered as an avenue for cancer development. Free radicals are produced in the body upon exposure to stress, cigarette smoke, alcohol, toxins found in personal care products, pesticides in foods, radiation from the s...

Tobacco exposure is the primary leading cause for cancer of the oral cavity, the airways and lung. The carcinogens in cigarette smoke have been linked as an environmental risk factor for causing genetic mutations in tumor suppressor, including TP53 (p53) which has been linked as a causative for occu...

The study demonstrates a deficit in knowledge about group behavior therapy and it shows that the level of education was associated with the knowledge. Additionally, previous attempts to quit smoking and the number of cigarettes used per day, influenced the participants' attitude and beliefs tow...

Vitiligo is a rare skin condition caused by an immune reaction. Vitiligo can occur anywhere on the body. This proposed explanation of vitiligo makes it clear that vitiligo is not linked to any other autoimmune diseases. The polymorphisms of some genes present in the immune system play a major functi...

G1896A switch is one of the hotspots in subjects affected with hepatitis B. This hotspot mutation is observed in all the different spectrum of hepatitis B, and it has a very dangerous and a long lasting effect. The major purpose of the study was to screen G1986A mutations at a large scale and also t...

The prevalence of cancer-associated anemia (CIA) is high, and the mechanisms governing its development remain poorly understood. Eryptosis, the suicidal cell death of red blood cells (RBCs), may account for CIA as it is triggered by clinically approved chemotherapeutics including cisplatin and pacli...

Prostate cancer is one of the most frequently diagnosed malignancies in developed countries and approximately 248,530 new cases of prostate cancer are likely to be diagnosed in the United States in 2021. During the late 1990s and 2000s, the prostate cancer-related death rate has decreased by 4% per ...

Abstract Artemisia absinthium (AA) is an indigenous medicine used for treatment of inflammation of the liver and chronic fever, and is studied as an antimalarial and anticancer agent. The focus of the current investigation was to determine the action and effect of AA on microRNAs (miRNAs) from breas...

There are very scanty reports on gastro-intestinal stromal tumors (GISTs), a very common tumor of mesenchymal cells in GIT track primary resistance to imatinib. This comprehensive study identifies the prevalence, clinical presentation and GIST genotype association in the imatinib naïve population. P...

The gut microbiota of honey bees (Apis mellifera) can be symbiotic or pathogenic and therefore, important for bee survival and honey production. To study gut cultivable bacteria of honey bees, 30 honey bee samples were collected from district Kohat of Khyber Pakhtunkhwa Province as there is no infor...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a potentially lethal pathogen recently found to be responsible for the pandemic coronavirus disease 2019 (COVID-19). At present PCR testing remains the standard method of diagnosing COVID-19 patients. Recently, testing for SARS-CoV-2 im...

Grass pollen exposure was associated with eosinophilic airway inflammation 1-2 days after exposure and airway obstruction 2-3 days after exposure. Adults and individuals with asthma, hay fever, and pollen sensitization may be at higher risk.

Although physicians were preferred and highly trusted, internet sources appeared to impact the medical knowledge of the population. The population still preferred to use internet search to obtain health information prior to a doctor's visit.

<sec> <title>BACKGROUND</title> Having a reliable source for health information is vital to build a strong foundation of knowledge, especially with the current revolution of the internet and social media, which raises many concerns regarding harmful effects on the health of the pub...

In these population-based samples, EBC NO_x was most strongly associated with atopic sensitization, rather than either current asthma or rhinitis, possibly indicating underlying increased airway inflammation associated with atopy. Therefore, EBC NO_x could...

LIAISON® XL Murex HBsAg Quant assay is a highly sensitive, specific and accurate screening assay for detecting wild type as well as mutant HBsAg.

Oxidative stress has a recognized role in the pathophysiology of asthma. Recently, interest has increased in the assessment of pH and airway oxidative stress markers. Collection of exhaled breath condensate (EBC) and quantification of biomarkers in breath samples can potentially indicate lung diseas...